‘Effectiveness of Continuing Professional Development’ project: a summary of findings

This article reports on a study examining continuing professional development (CPD) for consultant doctors. The aim of the study was to identify what promotes or inhibits the effectiveness of CPD and met the following objectives: comparing and contrasting the experiences of CPD across the range of specialties; identifying and describing the range of different models of CPD employed across the different specialties and clinical contexts; considering the educational potential of reflective practice in CPD and its impact on professional practice and exploring how different professionals judge the effectiveness of current CPD practices. Using a mixture of qualitative (interviews, letters, observation) and quantitative (online questionnaire) methods, the views of CPD providers and users were surveyed. Findings suggested that the effectiveness of CPD, as inferred from the comments made by interviewees and questionnaire respondents, relates to the impact on knowledge, skills, values, attitudes, behaviours and changes in practice in the work place. The quality of CPD was seen as inextricably linked to any improvements in the quality of the professional practices required for service delivery. There was widespread consensus as to the value of learning in professional settings. There was recognition that there needs to be a move away from tick boxes to the in-depth identification of learning needs and how these can be met both within and external to the work place, with learning being adequately enabled and assessed in all locations. In conclusion, it can be said that CPD is valued and is seen as effective when it addresses the needs of individual clinicians, the populations they serve and the organisations within which they work. However, the challenge for CPD may lie in the dynamic interaction between educational opportunities and service delivery requirements, as there may be occasions where they vie with each other for resources

The Neuronal EGF-Related Gene Nell2 Interacts with Macf1 and Supports Survival of Retinal Ganglion Cells after Optic Nerve Injury

Nell2 is a neuron-specific protein containing six epidermal growth factor-like domains. We have identified Nell2 as a retinal ganglion cell (RGC)-expressed gene by comparing mRNA profiles of control and RGC-deficient rat retinas. The aim of this study was to analyze Nell2 expression in wild-type and optic nerve axotomized retinas and evaluate its potential role in RGCs. Nell2-positive in situ and immunohistochemical signals were localized to irregularly shaped cells in the ganglion cell layer (GCL) and colocalized with retrogradely-labeled RGCs. No Nell2-positive cells were detected in 2 weeks optic nerve transected (ONT) retinas characterized with approximately 90% RGC loss. RT-PCR analysis showed a dramatic decrease in the Nell2 mRNA level after ONT compared to the controls. Immunoblot analysis of the Nell2 expression in the retina revealed the presence of two proteins with approximate MW of 140 and 90 kDa representing glycosylated and non-glycosylated Nell2, respectively. Both products were almost undetectable in retinal protein extracts two weeks after ONT. Proteome analysis of Nell2-interacting proteins carried out with MALDI-TOF MS (MS) identified microtubule-actin crosslinking factor 1 (Macf1), known to be critical in CNS development. Strong Macf1 expression was observed in the inner plexiform layer and GCL where it was colocalizied with Thy-1 staining. Since Nell2 has been reported to increase neuronal survival of the hippocampus and cerebral cortex, we evaluated the effect of Nell2 overexpression on RGC survival. RGCs in the nasal retina were consistently more efficiently transfected than in other areas (49% vs. 13%; n = 5, p<0.05). In non-transfected or pEGFP-transfected ONT retinas, the loss of RGCs was approximately 90% compared to the untreated control. In the nasal region, Nell2 transfection led to the preservation of approximately 58% more cells damaged by axotomy compared to non-transfected (n = 5, p<0.01) or pEGFP-transfected controls (n = 5, p<0.01)

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

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Exploring the Terminology, Definitions, and Forms of Post-Occupancy Evaluation (POE) in Landscape Architecture

While the concept of Post-Occupancy Evaluation (POE) is widely applied in landscape architecture and other relevant fields, the term POE is not well-defined. By reviewing and analysing a representative set of POE definitions collected from existing academic and grey literature using content analysis methods, this study aims to enhance understanding of the breadth of the concept and its relevant practices. Our research found that the concept of POE was developed in architecture in the 1970s and subsequently adopted in landscape architecture in the 1980s. With the growth of the field in architecture and its adaptation to landscape architecture, the scope of POE was significantly expanded over recent decades, and with this growth, there have been considerable divergences in definitions and understandings of how to carry out POE. A range of different evaluation objects and four evaluation models were identified by this study. By surveying the conceptual terrain of POE, our research establishes the need for practitioners to be aware of the breadth of the concept and the potential ambiguity surrounding what is meant by the approach. Consequently, practitioners need to be specific and explicit about their understanding of POE. The findings also demonstrate how interdisciplinary differences appear to have been overlooked when adapting POE from one discipline to another. We, therefore, argue that it is crucial to keep shaping and trimming the concept to support the adaption of POE processes into different disciplinary domains

Researching Theatre History and Historiography

How have theatre and performance research methods and methodologies engaged the expanding diversity of performing arts practices? How can students best combine performance/theatre research approaches in their projects? This book's 29 contributors provide hands-on answers to such questions. Challenging and debating received research wisdom and exploring innovative procedures for rigorous inquiry via archives, technology, practice-as-research, scenography, performer training, applied theatre/performance, body in performance and more, they create a focused compendium of future research options. Key Features Created in association with TaPRA, the leading UK Theatre and Performance Research organisation, with chapters produced by specialist groupings. Provides many detailed project case studies and examples - including successful practice-based PhDs - plus analysis of dynamic couplings between methods, methodologies and skill-sets. Introduction interrogates crucial qualities of performing arts research that constitute theatre and performance as, variously, single-, multi-, inter-, and trans-disciplinary. Contributors include: Maggie B. Gale (Chair of Drama, University of Manchester); Steve Dixon (Professor of Digital Performance, Brunel University); Joanne 'Bob' Whalley and Lee Miller (University Lecturers and founders Fictional Dogshelf Theatre Company); Simon Ellis and Rosemary Lee (independent performance/dance makers); Roberta Mock (Professor of Performance, University of Plymouth)